![]() Subscripts are attached at the end of these abbreviations to denote the number of double bonds outside the five-carbon ring in a given prostaglandin. The five major classes of prostaglandins are designated as PGA, PGB, PGE, PGF, and PGI. ![]() It is now known that they are synthesized in nearly all mammalian tissues and affect almost all organs in the body. They are called prostaglandins because they were originally isolated from semen found in the prostate gland. ![]() They are unsaturated fatty acids containing 20 carbon atoms and are synthesized from arachidonic acid-a polyunsaturated fatty acid-when needed by a particular cell. Prostaglandins are chemical messengers synthesized in the cells in which their physiological activity is expressed. ![]() \): Lipid Organization Based on Structural Relationships ![]()
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